Dominant views of personal identity in philosophy take some kind of psychological continuity or connectedness over time to be criterial for the identity of a person over time. Such views assign psychological states, particularly those necessary for narrative memory of some kind, special importance in thinking about the nature of persons. The extended mind thesis, which has generated much recent discussion in the philosophy of mind and cognitive science, holds that a person’s psychological states can physically extend beyond that person’s (...) body. Since “person” is a term of both metaphysical and moral significance, and discussions of both extended minds and personal identity have often focused on memory, this article explores the relevance of extended cognition for the identity of persons with special attention to neuroethics and memory. (shrink)

At the dawn of the computational era, immunology is at a crossroads: Its efforts to frame microbial-host interactions in combative, war-related terms no longer fit the larger picture of immune protection, and its focus on antimicrobial responses barely captures the diverse functions of the immune system, from tissue maintenance to cancer surveillance to development. As the classical view of immune processes becomes increasingly complex, the problem of self, individuality, mind-body interactions, and disease causation have stimulated extensive philosophical comment. Relating these (...) disparate research topics to changing avenues of theoretical studies, philosophy of immunology helps to reframe basic conceptions of the organism from an atomistic, insular entity to one characterized by fluidity, hybridity, and porosity. In addition, highlighting the role of the observer in experimental research, this interdisciplinary field has redefined classical demarcations between science and culture while advancing our understanding of biology as a fundamentally human endeavor. (shrink)

Philosophy of immunology is a subfield of philosophy of biology dealing with ontological and epistemological issues related to the studies of the immune system. While speculative investigations and abstract analyses have always been part of immune theorizing, until recently philosophers have largely ignored immunology. Yet the implications for understanding the philosophical basis of organismal functions framed by immunity offer new perspectives on fundamental questions of biology and medicine. Developed in the context of history of medicine, theoretical biology, and medical anthropology, (...) philosophy of immunology differs from these related branches of study in its focus on traditional philosophical questions concerning identity, individuality, ecology, cognition, scientific methodology and theory construction. This broad agenda derives from immunology’s multifaceted research program that has developed from its initial clinical challenges of host defense, transplantation, autoimmunity, tumor immunology, and allergy. In addition to these well-established research areas, immunity is now understood to play a central role in other physiological functions, development, ecology, and evolutionary mechanics. Holding together these diverse domains of inquiry lie philosophical commitments oriented by organismal identity. In this regard, pertinent issues are raised concerning cognition (organization of immune perception and information processing), the character of individuality (framed by the ecological context of immune-mediated assimilation and rejection), and the dynamics of complex systems (understood as holistic systems biology). Indeed, immunology, in the context of cognitive science, evolutionary biology, environmental sciences, and development provides multi-focal perspectives for philosophy of science. (shrink)

Somatic diversification of antigen receptor genes depends on the activity of enzymes whose homologs participate in a mutagenic DNA repair in unicellular species. Indeed, by engaging error-prone polymerases, gap filling molecules and altered mismatch repair pathways, lymphocytes utilize conserved components of genomic stress response systems, which can already be found in bacteria and archaea. These ancient systems of mutagenesis and repair act to increase phenotypic diversity of microbial cell populations and operate to enhance their ability to produce fit variants during (...) stress. Coopted by lymphocytes, the ancient mutagenic processing systems retained their diversification functions instilling the adaptive immune cells with enhanced evolvability and defensive capacity to resist infection and damage. As reviewed here, the ubiquity and conserved character of specialized variation-generating mechanisms from bacteria to lymphocytes highlight the importance of these mechanisms for evolution of life in general. (shrink)

Philosophers have no time. They are tired with philosophising. They doze off or even die of fatigue over yet another review, opinion, article, translation of works of an English-speaking philosophical genius, publishing and editing of a book. They are exhausted by the obligatory teaching, bored with listening to conference papers, depressed by defences of post-doctoral theses, hopeless against plagiarism, out-of-breath chasing credits, worn out by English articles, crumpled and ill-treated by institutions, tired with maintaining and co-creating them, jaded by the (...) speed of information transfer, weakened by the absence of lively thought, knackered by the number of graduates and languid due to their quality, depressed by discord, exhausted by the continuous game of getting lost and finding oneself in science and the Academy. -/- In this ruffle, shabbiness and depletion they undertake with difficulty yet another fight for philosophy, in which they often represent the lost cause and happen to be merciless to each other, sometimes they give up and even moan. Their tiredness is accompanied by heavy steps and sluggishness. Barely alive they keep on living. Somewhere they find the energy, they live for something, serve something. In the article, following the smartest of philosophers, Socrates, and his defence speech, the speech in defence of his life, we explain where the philosophers find the energy, what they live for and what, often in contradiction to their own declarations, they serve. (shrink)

This paper argues that the well-established fact of political irrationality imposes substantial constraints on how governments may combat the threat of political misinformation. Though attempts at regulating misinformation are becoming increasingly popular, both among policymakers and theorists, I intend to show that, for a wide range of anti-misinformation interventions (collectively termed “debunking” and “source labeling”), these attempts ought to be abandoned. My argument relies primarily on the fact that most people process politically-relevant information in biased and motivated ways. Since debunking (...) or factual correction of politically relevant misinformation (as well as source labeling) themselves consist of providing politically-relevant information, they are also very likely to be processed in irrational ways. This makes it extremely difficult to effectively correct people’s political beliefs and political information processing. Since governments should not pursue policies likely to be futile, they should refrain from mandating such interventions. My conclusion is of relevance to considerable literature in digital ethics of misinformation. It shows that many celebrated works in the field ignore political irrationality and fail to consider its implications. (shrink)

The extent to which normal (nonmalignant) cells of the body can evolve through mutation and selection during the lifetime of the organism has been a major unresolved issue in evolutionary and developmental studies. On the one hand, stable multicellular individuality seems to depend on genetic homogeneity and suppression of evolutionary conflicts at the cellular level. On the other hand, the example of clonal selection of lymphocytes indicates that certain forms of somatic mutation and selection are concordant with the organism-level fitness. (...) Recent DNA sequencing and tissue physiology studies suggest that in addition to adaptive immune cells also neurons, epithelial cells, epidermal cells, hematopoietic stem cells and functional cells in solid bodily organs are subject to evolutionary forces during the lifetime of an organism. Here we refer to these recent studies and suggest that the expanding list of somatically evolving cells modifies idealized views of biological individuals as radically different from collectives. (shrink)

The idea that the immune system distinguishes between self and non-self was one of the central assumptions of immunology in the second half of 20 th century. This idea influenced experimental design and data interpretation. However, in the face of new evidence there is a need for a new conceptual framework in immunology.

According to grounding necessitarianism if some facts ground another fact, then the obtaining of the former necessitates the latter. Proponents of grounding contingentism argue against this claim, stating that it is possible for the former facts to obtain without necessitating the latter. In this article I discuss a recent argument from restricted accidental generalisations provided by contingentists that advances such possibility. I argue that grounding necessitarianism can be defended against it. To achieve this aim, I postulate a relationship between grounding (...) and essence by introducing a notion of individual essences understood as a set of essential properties that individuate its bearer. According to a proposed view grounding holds in virtue of identities of its relata, which are in turn determined by their respective individual essences. From there I claim that if grounding holds in virtue of the individual essences of its relata, then it is possible to resist the objection from restricted accidental generalisations and maintain a view that grounds necessitates what is grounded. (shrink)

It is said that transcendental phenomenology faces an unavoidable aporia, according to which it is perfectly justified to accept the claim that the transcendental ego constitutes the sense of all external being, including other subjects, as well as the claim that other subjects constitute the sense of all external objects, since they are a community of transcendental egos. The essence of the aporia is that it is impossible to accept both of these claims if one accepts the conceptual schema of (...) transcendental phenomenology. In the article, I present an interpretation of transcendental phenomenology which allows one to avoid such consequences. Firstly, the static theory of intersubjectivity presented in Ideas of Pure Phenomenology and Carthesian Meditations is reconstructed and analyzed. Attention is devoted to the issues of phenomenological reduction and constitution of sense. Afterwards, it is argued that one should distinguish two kinds of constitutive processes: one understood as an activity of the sole transcendental ego (self), and the second one as an activity of the community of transcendental egos. It is claimed that both processes are mutually connected. Moreover, it seems that the second kind of constitution is metaphysically prior then the former one. This claim will allow one to overcome solipsistic interpretations of transcendental phenomenology and to overcome the aporia presented. (shrink)

In this paper, I discuss a connection between quidditism and the Lewisian principle of recombination. I begin by reconstructing a typical characterisation of a Lewisian principle of recombination, followed by an explanation of quidditism. In the remainder, I argue that a proponent of a Lewisian principle of recombination cannot endorse quidditism without some important modifications of her view.

Central to vaccination-induced responses, antibodies are suggested by Vaz to operate as observer-dependent entities that owe their status to categorization schemes of immunologists. Inspired by color research by Maturana, he argues that antibodies should be distinguished from immunoglobulins, which unlike the former can be considered as constituents of structural dynamics of an organism, products of millions of years of evolution. However, a deeper understanding of the historical roots of the concept of immunoglobulin and associated “languaging” and naming processes reveals that (...) immunoglobulins, as much as antibodies, are contingent on conceptual schemes of immunology. (shrink)

To enable microbial colonisation of the gut mucosa, the intestinal immune system must not only react to danger signals but also recognize cues that indicate safety. Safety recognition, paradoxically, is mediated by the same environmental sensors that are involved in signalling danger. Indeed, in addition to their well established role in inducing inflammation in response to stress signals, pattern recognition receptors (PRRs) and a variety of metabolic sensors also promote gut-microbiota symbiosis by responding to "microbial symbiosis factors", "resolution-associated molecular patterns", (...) markers of energy extraction and other signals indicating the absence of pathogenic infection and tissue damage. Here we focus on how the paradoxical role of immune receptors and other environmental sensors define the microbiota signature of the individual. (shrink)

According to strong pluralism, objects distinct by virtue of their modal properties can coincide. The most common objection towards such view invokes the so-called Grounding Problem according to which the strong pluralist needs to explain what the grounds are for supposed modal differences between the coincidents. As recognized in the literature, the failure to provide an answer to the Grounding Problem critically undermines the plausibility of strong pluralism. Moreover, there are strong reasons to believe that strong pluralists cannot provide an (...) explanation of the Grounding Problem. In this paper, we argue that strong pluralism can be motivated independently of the successful answer to the Grounding Problem. In order to achieve that aim, we provide a haecceitistic interpretation of strong pluralism according to which strong pluralism should be read as a position committed to the existence of primitive individuals, i.e., the individuals that have their criteria of individuation independently of their qualitative profiles. That said, we do not aim at defending haecceitism. Instead, our aim is rather modest: we want to provide a new way for the strong pluralist to supplement his view to make it more watertight. (shrink)

Commensal and pathogenic organisms employ camouflage and mimicry to mediate mutualistic interactions and predator escape. However, the immune mechanisms accounting for the establishment and maintenance of symbiotic bacterial populations are poorly understood. A promising hypothesis suggests that molecular mimicry, a condition in which different organisms share common antigens, is a mechanism of establishing tolerance between commensals and their hosts. On this view, certain bacteria may mimic the structural features of some of their host’s T-cell receptors (TCRs), namely those that survive (...) thymic selection due to their lack of complementarity to self-antigens. With such “holoimmunity” the mimicking micro-organisms avoid immune recognition as the copied TCRs become mirror images of an extended super-organismal self, consisting of symbiotic and host antigens. Accordingly, analysis of genomic and metagenomic data suggests a tripartite mimicry between TCRs, self-antigens, and commensal antigens that would serve as the basis for immune tolerance between these populations. And conversely, in an autoimmune scenario, both symbiotic microbes and the mimicked host tissue would be targeted for immune destruction. (shrink)

There is a deep-seated neopositivist view which regards the language of science as a neutral medium of communication, radically different from indirect symbolic forms of discourse characteristic of arts and humanities. But naturalists, like poets and social scientists, also draw on the dominant images in their culture to organize their thoughts and simplify complex concepts. By conceptualizing one thing in terms of another, metaphors in science not only aid mutual communication between researchers but also structure their understanding of experience and (...) reality. Too transparent to be noticed and critically analyzed within the framework of science itself, metaphors act as lenses, making selected aspects of complex phenomena visible to study and investigation (Reynolds 2018). By linking two seemingly unrelated ideas, for example, those of a machine and DNA replication, metaphors establish new interactions of meaning evoking shared associated connotations between these interacting concepts (Black 1962). This, in turn, may not only transform the perception of a target domain but also open up new prospects for experimental and interpretative avenues. Understanding Metaphors by Andrew Reynolds draws on this vision of metaphors as indispensable tools of scientific thinking to elucidate their role in the life sciences. (shrink)

A standard contemporary formulation of essentialism defines essential properties with a help of a concept of possible worlds. It is often argued that in order to use possible worlds effectively, facts about transworld identity of individuals need to be determined. In this paper I discuss how essentialist might attempt the issue of transworld identity of individuals. Specifically, I analyze a connection between essentialism and the two theories that explain the transworld identity issue, that is, haecceitism and antihaecceitism. I provide a (...) detailed analysis of different variants of antihaecceitism and argue, that all of them are incompatible with basic intuitions that stay behind essentialism. In contrast to that, I defend a position that essentialism ought to be combined with some form of haecceitism. In the remainder of this paper I provide the two ways through which essentialist might be a haecceitist. (shrink)

The paper is a survey of contemporary quidditism, understood as two interrelated metaphysicalpositions — recombinatorial quidditism, which is an account of the nature of possibilities, andindividuation quidditism, which is concerned with the problem of how to individuate properties.I have three aims: to examine the commitments and consequences of both views, to investigatethe relationships between them, and to sketch the logic of the dispute between structuralism andquidditism. I explain how these views relate to Ramseyan humility, according to which we cannotknow the (...) fundamental structure of the world. (shrink)

In this article I defend a view according to which facts that express metaphysical grounding are grounded in essences of properties involved into a given grounding relationship. To justify this view, first, I present some reasons for a claim that metaphysical grounding is grounded. In the next step I discuss two theories that explain what are the grounds for grounding: a theory that involves a notion of a superinternal relation and a theory that uses a notion of essences of properties. (...) I argue that later theory is preferable over the former. (shrink)

According to actualism about possible worlds everything that exists is actual. Possible worlds and individuals are actually existing abstract parts of the actual world. Aristotelian actualism is a view that there are only actual individuals but no possible ones, nor their individual abstract representatives. Because of that, our actualist account of modality should differ depending on whether it concerns actual individuals or possible ones. The main goal of the dissertation is to develop a metaphysical framework for Aristotelian actualism. Chapter 1 (...) explains basic issues associated with the possible world approach to modality. I overview modal realist and actualist views on possible worlds and explain why I support the actualist approach. Subsequently, I introduce a distinction between Platonic and Aristotelian actualism, and discuss some semantic issues associated with actualism as such. In Chapter 2 I argue that Aristotelian actualism, modeled on linguistic ersatzism, is preferable over its Platonic counterpart. Subsequently, I propose a metaphysical framework for Aristotelian ersatzism which is based on a claim that our modal concepts work differently for actual and possible individuals. In order to explain that claim I introduce three specific differences concerning modal features of actual and possible individuals: (a) Representational Difference, according to which actual and possible individuals are represented differently by possible worlds; (b) Metaphysical Difference, according to which actual and possible individuals are represented by possible worlds as having different metaphysical nature; (c) Modal Difference, which says while there are singular and contingent possibilities involving actual individuals, all possibilities about possible individuals are general and necessary. I propose to interpret those differences in terms of the doctrines of haecceitism, antihaecceitism and existentialism. There is however no consensus on how those views should be characterized. Chapters 3, 4, and 5 focus on providing a precise characterization of those doctrines. Chapter 3 focuses on the doctrines of modal haecceitism and antihaecceitism, which I view as opposite accounts of how possible worlds represent possibilities. According to modal haecceitism what possible worlds say about particular individuals does not supervene on what they say qualitatively. Modal antihaecceitism is a denial of such a claim. Chapter 4 concerns metaphysical haecceitism and antihaecceitism, which I take to be alternative accounts of the fundamental structure of reality. For the metaphysical haecceitist reality contains irreducible singular facts, while for the metaphysical antihaecceitist reality is purely qualitative and general. Chapter 5 focuses on an argument between existentialists and antiexistentialists. Existentialists claim that there are contingent singular propositions, while antiexistentialists deny that. I defend existentialism against antiexistentialist counterarguments, as well as criticize some of the antiexistentialist accounts of singular propositions modeled on the notion of individual essence. In Chapter 6, by appealing to the results of investigations conducted in Chapters 3, 4 and 5, I reconsider Representational, Metaphysical and Modal Differences. According to a view that I propose: (a) Representational Difference entails (extreme) modal haecceitism for actual individuals but (extreme) modal antihaecceitism for possible individuals; (b) Metaphysical Difference entails metaphysical haecceitism (individualism) for actual individuals, but metaphysical antihaecceitism (generalism) for possible individuals; finally (c) Modal Difference entails existentialism: while there are singular and contingent possibilities involving actual individuals, all possibilities about possible individuals are general and necessary. In Chapter 6, I also explain the implications of those views for the various issues, including transworld identity, essentialism, or the modal status of modal space. Lastly, Chapter 7 overviews some semantic and metaphysical applications of Aristotelian ersatzism. I explain how it manages to accommodate Kripkean semantics and how it is able to account for the possibilities of indiscernibles, alien individuals and iterated modalities. I also address some possible objections to my proposal, including an issue of implicit representation and the Humphrey objection. (shrink)

Extended cognition holds that cognitive processes sometimes leak into the world (Dawson, 2013). A recent trend among proponents of extended cognition has been to put pressure on phenomena thought to be safe havens for internalists (Sneddon, 2011; Wilson, 2010; Wilson & Lenart, 2014). This paper attempts to continue this trend by arguing that music perception is an extended phenomenon. It is claimed that because music perception involves the detection of musical invariants within an “acoustic array”, the interaction between the (...) auditory system and the musical invariants can be characterized as an extended computational cognitive system. In articulating this view, the work of J. J. Gibson (1966, 1986) and Robert Wilson (1994, 1995, 2004) is drawn on. The view is defended from several objections and its implications outlined. The paper concludes with a comparison to Krueger’s (2014) view of the “musically extended emotional mind”. (shrink)

part, whole, ideal quality, foundation, unity, space, topoontology, topophilosophy, formal ontology, topology, mathematical philosophy, topology, topology of the person, topology of mind, mathematics in philosophy, mereology, mereotopology, phenomenology, Benedict Bornstein, Edmund Husserl, Roman Ingarden, Kurt Lewin, René Thom.

Through cutting-edge accounts and interdisciplinary critiques of shame, this collection responds to the epidemic of gendered violence that the world witnesses daily. Contributors expose and challenge how oppression and violence connect to regimes of injustice that have dominated modern times.

Istnieje spór w obrębie filozofii sięgający już starożytności i polemiki Platona z Sofistami, dotyczący ugruntowania metafizyki jako dziedziny autonomicznej, która byłaby zdolna do badania swoistych elementów rzeczywistości, przysługujących tylko i wyłącznie metafizyce. We wstępnych rozważaniach przedstawiamy sposób, w jaki ten spór można rozumieć oraz jak można go rozwiązać. Tezą metafilozoficzną naszych analiz będzie stwierdzenie, że w celu ugruntowania metafizyki musimy wskazać na swoiste doświadczenie, które mogłoby zapewnić bezpośredni dostęp poznawczy do abstrakcyjnego przedmiotu metafizyki. W niniejszych badaniach, rolę tego doświadczenia będzie (...) pełnić intuicja, którą utożsamiamy z poznaniem apriorycznym – ujmowanym jednak nie jako poznanie pojęciowe bądź dedukcyjne – lecz jako poznanie naoczne, które (używając języka fenomenologii) źródłowo (materialnie) prezentuje nam swoistą sferę przedmiotową. By lepiej zrozumieć zjawisko intuitywnego poznania do którego bardzo często filozofowie implicite się odnosili (rzadziej zaś wprost) zrekonstruujemy stanowisko E. Chudnoffa. W trakcie rekonstrukcji skupimy się na najistotniejszych cechach poznania intuitywnego, które będą kluczem zarówno do zrozumienia wielości tradycyjnych już odniesień i niejawnych odwoływań do intuicji, jak i sposobem poprzez który możliwe stanie się ustalenie warunków możliwości ugruntowania metafizyki jako dziedziny autonomicznego badania rzeczywistości. (shrink)

W artykule rozważana jest koncepcja nagiego substratu w kontekście problemu indywiduacji. Głównym celem tekstu jest obrona teorii nagiego substratu (TNS) przed klasycznymi oraz współczesnymi zarzutami. Tok rozważań jest następujący: Autor we wstępie definiuje problem jednostkowienia i systematyzuje obecną dyskusję nad tym zagadnieniem. Następnie skupia się na porównaniu teorii wiązki i teorii nagiego substratu, ujętych jako alternatywne wyjaśnienia jednostkowości przedmiotów. Celem porównania dwóch teorii jest przedstawienie motywacji stojących za przyjęciem TNS. Głównym elementem tekstu jest punkt 2, w którym analizuje podstawowe założenia (...) TNS oraz odpiera wytaczane wobec niej zarzuty. Autor wykazuje, że warunkiem możliwości przezwyciężenia zarzutów z przeludnienia i regresu jest modyfikacja TNS i postulat teorii identyczności. (shrink)

The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders that function by hijacking the built-in Ubiquitin-Proteasome pathway. This review mainly focuses on the general design and functioning of PROTACs as well as current advancements in the development of PROTACs as anticancer therapies. Particular emphasis is given to PROTACs designed against various (...) types of Leukemia/Blood malignancies. (shrink)

1. The Situation in Cognition 2. Situated Cognition: A Potted Recent History 3. Extensions in Biology, Computation, and Cognition 4. Articulating the Idea of Cognitive Extension 5. Are Some Resources Intrinsically Non-Cognitive? 6. Is Cognition Extended or Only Embedded? 7. Letting Nature Take Its Course.

The impressive variation amongst biological individuals generates many complexities in addressing the simple-sounding question what is a biological individual? A distinction between evolutionary and physiological individuals is useful in thinking about biological individuals, as is attention to the kinds of groups, such as superorganisms and species, that have sometimes been thought of as biological individuals. More fully understanding the conceptual space that biological individuals occupy also involves considering a range of other concepts, such as life, reproduction, and agency. There has (...) been a focus in some recent discussions by both philosophers and biologists on how evolutionary individuals are created and regulated, as well as continuing work on the evolution of individuality. (shrink)

The Eugenic Mind Project is a wide-ranging, philosophical book that explores and critiques both past and present eugenic thinking, drawing on the author’s intimate knowledge of eugenics in North America and his previous work on the cognitive, biological, and social sciences, the fragile sciences. Informed by the perspectives of Canadian eugenics survivors in the province of Alberta, The Eugenic Mind Project recounts the history of eugenics and the thinking that drove it, and critically engages contemporary manifestations of eugenic thought, newgenics. (...) An accessible, original work of scholarship adopting what the author calls a standpoint eugenics, this book focuses on the roots of eugenic thinking past and present. It will provoke and enrich discussions about human nature and human diversity, the social uses of biotechnology, and social policy governing future generations. You can download the preface and acknowledgements here. (shrink)

This paper examines the standard view of realization operative incontemporary philosophy of mind, and proposes an alternative, generalperspective on realization. The standard view can be expressed, insummary form, as the conjunction of two theses, the sufficiency thesis andthe constitutivity thesis. Physicalists of both reductionist and anti-reductionist persuasions share a conception of realization wherebyrealizations are determinative of the properties they realize and physically constitutive of the individuals with those properties. Centralto the alternative view that I explore here is the idea that (...) the requisite,metaphysically robust notion of realization is ineliminably context-sensitive. I shall argue that the sufficiency and constitutivity theses aretypically not jointly satisfied by any one candidate realizer, and that goingcontext-sensitive in one's metaphysics is preferable to the standard view.The context-sensitive views developed here are implicit in a range ofcommon views in both the philosophy of mind and the philosophy of biology,even if they have not been explicitly articulated, and even though theyundermine other views that are commonly endorsed. (shrink)

This volume of twelve specially commissioned essays about species draws on the perspectives of prominent researchers from anthropology , botany, developmental psychology , the philosophy of biology and science, protozoology, and zoology . The concept of species has played a focal role in both evolutionary biology and the philosophy of biology , and the last decade has seen something of a publication boom on the topic (e.g., Otte and Endler 1989; Ereshefsky 1992b; Paterson 1994; lambert and Spence 1995; Claridge, Dawah, (...) and Wilson 1997; Wheeler and Meier 1999; Howard and Berlocher 1998). (shrink)

We introduce two notions–the shadows and the shallows of explanation–in opening up explanation to broader, interdisciplinary investigation. The shadows of explanation refer to past philosophical efforts to provide either a conceptual analysis of explanation or in some other way to pinpoint the essence of explanation. The shallows of explanation refer to the phenomenon of having surprisingly limited everyday, individual cognitive abilities when it comes to explanation. Explanations are ubiquitous, but they typically are not accompanied by the depth that we might, (...) prima facie, expect. We explain the existence of the shadows and shallows of explanation in terms of there being a theoretical abyss between explanation and richer, theoretical structures that are often attributed to people. We offer an account of the shallows, in particular, both in terms of shorn-down, internal, mental machinery, and in terms of an enriched, public symbolic environment, relative to the currently dominant ways of thinking about cognition and the world. (shrink)

Does the Ship of Theseus present a genuine puzzle about persistence due to conflicting intuitions based on “continuity of form” and “continuity of matter” pulling in opposite directions? Philosophers are divided. Some claim that it presents a genuine puzzle but disagree over whether there is a solution. Others claim that there is no puzzle at all since the case has an obvious solution. To assess these proposals, we conducted a cross-cultural study involving nearly 3,000 people across twenty-two countries, speaking eighteen (...) different languages. Our results speak against the proposal that there is no puzzle at all and against the proposal that there is a puzzle but one that has no solution. Our results suggest that there are two criteria—“continuity of form” and “continuity of matter”— that constitute our concept of persistence and these two criteria receive different weightings in settling matters concerning persistence. (shrink)

This paper explores the relationship between eugenics, disability, and dehumanization, with a focus on forms of eugenics beyond Nazi eugenics.

This article makes a case for the capacity of "social practice" accounts of agency and freedom to criticize, resist, and transform systemic forms of power and domination from within the context of religious and political practices and institutions. I first examine criticisms that Michel Foucault's analysis of systemic power results in normative aimlessness, and then I contrast that account with the description of agency and innovative practice that pragmatist philosopher Robert Brandom identifies as "expressive freedom." I argue that Brandom can (...) provide a normative trajectory for Foucault's diagnoses of power and domination, helping to resolve its apparent lack of ethical direction. I demonstrate that Foucault, in turn, presents Brandom with insights that might overcome the charges of abstraction and conservatism that his pragmatic inferentialism frequently encounters. The result is a vindication of social practice as an analytical lens for social criticism that is at once both immanent and radical. (shrink)

Parkinson's Disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms generally come on slowly over time. Early in the disease, the most obvious are shaking, rigidity, slowness of movement, and difficulty with walking. Doctors do not know what causes it and finds difficulty in early diagnosing the presence of Parkinson’s disease. An artificial neural network system with back propagation algorithm is presented in this paper for helping doctors in identifying (...) PD. Previous research with regards to predict the presence of the PD has shown accuracy rates up to 93% [1]; however, accuracy of prediction for small classes is reduced. The proposed design of the neural network system causes a significant increase of robustness. It is also has shown that networks recognition rates reached 100%. (shrink)

This paper tries to determine the philosophical nature of language, its functions, structure and content. It also explains the concept of natural language, ordinary and ideal language i.e. how there is a need of artificial perfect logical language without errors and unclearness in that language. This paper further shows the logical form of language with its syntactical, semantical, innate and acquired criteria for the evaluation of the languages. It deals with the analysis of language to clear what is unclear, to (...) know what is unknown, to make definite what is vague. In this paper I used the method; logical method for interpretation and argumentation, analytical method for simplification, and critical method to investigate the real domain of language. This paper does not deal with ordinary functions of the language but it deals with the conceptual and modular functions of the language. The fundamental aim of this written up is to determine the analytical approach of Wittgenstein to sketch the ‘language as a tool to discuss the state of affairs or facts of the worlds that is also what philosophy does. This paper describes the contributions of rationalism and empiricism in the field of knowing the truths of language. (shrink)

The Westermarck Effect posits that intimate association during childhood promotes human incest avoidance. In previous work, I articulated and defended a version of the Westermarck Effect by developing a phylogenetic argument that has purchase within primatology but that has had more limited appeal for cultural anthropologists due to their commitment to conventionalist or culture-first accounts of incest avoidance. Here I look to advance the discussion of incest and incest avoidance beyond culture-first accounts in two ways. First, I shall dig deeper (...) into the disciplinary grooves within cultural anthropology that make attractive the view that incest has a naturalness to it that is countered only or primarily by explicit social rules, such as taboos. Second, I further explore the emerging, post-conventionalist view of incest avoidance in a more positive vein by elaborating on the nature of the Westermarckian mechanism and how it relates to such explicit social rules and our innate biological endowments. One general aim here is to overcome the bifurcation between perspectives that are seen as biological and those seen as cultural, preempting or countering the claim that rejecting culture-first accounts entails a form of biological reductionism, a general aim I have pursued in related publications on bioessentialism about kinship. (shrink)

I think there is something to be said in a positive and constructive vein about collective intentionality in non-human animals. Doing so involves probing at the concept of collective intentionality fairly directly (Section 2), considering the various forms that collective intentionality might take (Section 3), showing some sensitivity to the history of appeals to that concept and its close relatives (Section 4), and raising some broader questions about the relationships between sociality, cognition, and institutions by discussing two different possible cases (...) of collective intentionality in non-human animals: that of the social insects (Section 5) and that of highly social mammals, such as canines (Section 6). If the discussion here is on track, then the widely shared perspective on collective intentionality exemplified by the work of Searle and Tomasello needs to be reconsidered. (shrink)

Rules serve many important functions in society. One such function is to codify, and make public and enforceable, a society's desired prescriptions and proscriptions. This codification means that rules come with predefined punishments administered by third parties. We argue that when we look at how third parties punish rule violations, we see that rules and their punishments often serve dual functions. They support and help to maintain cooperation as it is usually theorized, but they also facilitate the domination of marginalized (...) others. We begin by reviewing literature on rules and third-party punishment, arguing that a great deal of punishment research has neglected to consider the unique power of codified rules. We also argue that by focusing on codified rules, it becomes clear that the enforcement of such rules via third-party punishment is often used to exert control, punish retributively, and oppress outgroup members. By challenging idealized theory of rules as facilitators of social harmony, we highlight their role in satisfying personal punishment motives, and facilitating discrimination in a way that is uniquely justifiable to those who enforce them. (shrink)

Philosophy of history is the conceptual and technical study of the relation which exists between philosophy and history. This paper tries to analyze and examine the nature of philosophy of history, its methodology and ideal development. In this I have tried to set the limits of knowledge to know the special account of Hegel’s idealistic view about philosophy of history. In this paper I have also used the philosophical methodology and philosophy inquiry, quest and hypothesis to discuss the Hegel’s idealistic (...) concept of philosophy of history. It also examines and demonstrates the views of other idealist philosophers like, Socrates, Plato and Aristotle. It also shows the how history of mathematics is a complementary of idealism as most of philosophers who were idealists are also great mathematicians. In this paper we are investigation the epistemological approach, logical and metaphysical approach to study the nature of history, meaning of history and structure of history. (shrink)

The aim of this paper is to examine the nature, scope and importance of philosophy in the light of its relation to other disciplines. This work pays its focus on the various fundamental problems of philosophy, relating to Ethics, Metaphysics, Epistemology Logic, and its association with scientific realism. It will also highlight the various facets of these problems and the role of philosophers to point out the various issues relating to human issues. It is widely agreed that philosophy as a (...) multi-dimensional subject that shows affinity to others branches of philosophy like, Philosophy of Science, Humanities, Physics and Mathematics, but this paper also seeks, a philosophical nature towards the universal problems of nature. It evaluates the contribution and sacrifices of the great sages of philosophers to promote the clarity and progress in the field of philosophy. (shrink)

This study identifies global factors conditioning the global problematics of the direction of social development. Global threats were evaluated and defined as dangerous processes, phenomena, and situations that cause harm to health, safety, well-being, and the lives of all humanity, and require removal. The essence of global risks was defined. These risks were defined as events or conditions that may cause a significant negative effect for several countries or spheres within a strategic period if they occur. Global problems were conceptualized. (...) These problems were defined as phenomena, matters, and situations that are not completely understandable, interesting, actual, require solving and regulation, and in addition do not have unified solutions. Current global challenges were analyzed, defined as strategic guidelines that cause transformational changes and are receiving attention from humanity. Global trends were defined as courses of social development. The composition and role of global actors were described, and defined as international organizations, leading states, regional organizations, powerful corporations, institutional investors, large cities, and well-known personalities. The directions of positive courses of social development were developed by means of using the authors’ mechanism of solving the global problematics. (shrink)

The role of evolutionary theory at the origin of life is an extensively debated topic. The origin and early development of life is usually separated into a prebiotic phase and a protocellular phase, ultimately leading to the Last Universal Common Ancestor. Most likely, the Last Universal Common Ancestor was subject to Darwinian evolution, but the question remains to what extent Darwinian evolution applies to the prebiotic and protocellular phases. In this review, we reflect on the current status of evolutionary theory (...) in origins of life research by bringing together philosophy of science, evolutionary biology, and empirical research in the origins field. We explore the various ways in which evolutionary theory has been extended beyond biology; we look at how these extensions apply to the prebiotic development of (proto)metabolism; and we investigate how the terminology from evolutionary theory is currently being employed in state-of-the-art origins of life research. In doing so, we identify some of the current obstacles to an evolutionary account of the origins of life, as well as open up new avenues of research. (shrink)

The article is devoted to the increasing role of tourism in the world economy. The dynamics of international tourism indicators is investigated. The main global innovations in the tourism industry are identified: the growth of tourism types; the application of qualitatively new solutions of scientific and methodological and applied character; growing of tourism influence on the society; the existence of synergistic effect in the tourist industry as a result of combination of subjects efforts at all management levels; changing of the (...) role of internal and external factors that encourage innovative tourism development. In the article, the interaction of global processes on tourism innovations is defined. These processes are: intellectualization, informatization, cooperation, formation of the global tourism market, liberalization of the national tourism markets, increased competition and the spread of transnationalization. (shrink)

Enterprise Risk Management involves the process of identification, evaluation, treatment, and communication regarding risks throughout the enterprise. To support the tasks associated with this process, several frameworks and modeling languages have been proposed, such as the Risk and Security Overlay (RSO) of ArchiMate. An ontological investigation of this artifact would reveal its adequacy, capabilities, and limitations w.r.t. the domain of risk and security. Based on that, a language redesign can be proposed as a refinement. Such analysis and redesign have been (...) executed for the risk elements of the RSO grounded in the Common Ontology of Value and Risk. The next step along this line of research is to address the following research problems: What would be the outcome of an ontological analysis of security-related elements of the RSO? That is, can we identify other semantic deficiencies in the RSO through an ontological analysis? Once such an analysis is provided, can we redesign the security elements of the RSO accordingly, in order to produce an improved artifact? Here, with the aid of the Reference Ontology for Security Engineering (ROSE) and the ontological theory of prevention behind it, we address the remaining gap by proceeding with an ontological analysis of the security-related constructs of the RSO. The outcome of this assessment is an ontology-based redesign of the ArchiMate language regarding security modeling. In a nutshell, we report the following contributions: (1) an ontological analysis of the RSO that identifies six limitations concerning security modeling; (2) because of the key role of the notion of prevention in security modeling, the introduction of the ontological theory of prevention in ArchiMate; (3) a well-founded redesign of security elements of ArchiMate; and (4) ontology-based security modeling patterns that are logical consequences of our proposal of redesign due to its underlying ontology of security. As a form of evaluation, we show that our proposal can describe risk treatment options, according to ISO 31000. Finally, besides presenting multiple examples, we proceed with a real-world illustrative application taken from the cybersecurity domain. (shrink)

Efforts by governments, firms, and patients to deliver pioneering drugs for critical health needs face a challenge of diminishing efficiency in developing those medicines. While multi-sectoral collaborations involving firms, researchers, patients, and policymakers are widely recognized as crucial for countering this decline, existing incentives to engage in drug development predominantly target drug manufacturers and thereby do little to stimulate collaborative innovation. In this mini review, we consider the unexplored potential within pharmaceutical regulations to create novel incentives to encourage a diverse (...) set of actors from the public and private spheres to engage in the kind of collaborative knowledge exchange requisite for fostering enhanced innovation in early drug development. (shrink)

Matteo Ricci (1552-1610) was an Italian Jesuit and one of the first Christian missionaries to China in the modern era. He was a genuine polymath—a translator, cartographer, mathematician, astronomer, and musician. Above all, Ricci was a missionary for the gospel. As we briefly examine his 1603 seminal work, The True Meaning of the Lord of Heaven, our hope is that we, as evangelical educators, will perceive some of the deeper principles necessary for our own missionary work among unreached people.